After defeating Mundus with the help of Trish, they embrace and Trish cries.  Dante states that devil's never cry, therefore she is human.  The ceiling than caves in and the plane from early in the game lands on the floor.  After flying it through caves to safty, the island explodes.  Dante states that the evil will be back someday.  Trish states that it doesn't matter because they will stop them again.

The game cuts back to where it started.  However, the "Devil May Cry" store is now called "Devil Never Cry".  They get a phone call and go to kill the monsters in 5 minutes.